I’m always on the lookout for new evidence for nurses on the benefits or harms of common, simple things that they do for their patients. For nurses working with patients undergoing surgery, here’s the latest on preventing unintentional perioperative hypothermia.
The problem
Patients can get cold during surgery, from a combination of factors including uncovered skin, the action of anaesthetic drugs and the administration of cold fluids, either intravenously (IV) or to irrigate body parts during surgery. RiskA way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. of inadvertent perioperative hypothermia varies widely, from 1.5% to 20% according to audit reports.
Shivering on waking after anaesthesia is both unpleasant for the patient and a risk factorAn aspect of a person's condition, lifestyle or environment that affects the chance of them getting a disease. For example, cigarette smoking is a risk factor for lung cancer. for cardiovascular complications. Some studies have shown that intraoperative hypothermia with vasoconstriction slows healing and increases the riskA way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. of surgical wound infection. Even moderate hypothermia (35 °C) can change coagulation mechanisms and with decreased platelet activity the patient is more likely to bleed. It can also reduce the metabolic rateThe speed or frequency of occurrence of an event, usually expressed with respect to time. For instance, a mortality rate might be the number of deaths per year, per 100,000 people. and prolong the effect of certain anaesthetic drugs.
The solutions?

Can using warm fluids help patients stay warm and help prevent complications?
The clinical effectiveness of different methods of warming has been assessed in a NICE guideline, which concludes that there is sufficient evidence of clinical and cost effectivenessThe ability of an intervention (for example a drug, surgery, or exercise) to produce a desired effect, such as reduce symptoms. to make recommendations on the use of forced air warming (using a machine to force warm air through the patient’s blankets) to prevent and treat perioperative hypothermia, but this only include studies published up to 2007 and is currently under review.
Several Cochrane reviews have explored different aspects of this topic. This week, a new review from the Cochrane Anaethesia Group was published, pulling together the evidence on warming intravenous and irrigation fluids to prevent inadvertent perioperative hypothermia. Last year, another new Cochrane review looked at evidence on whether extra insulation, from reflective blankets or clothing, or forced air warming, could prevent perioperative hypothermia.
Can using warm fluids prevent hypothermia?
The reviewers found 24 randomised controlled trialsA trial in which a group (the ‘intervention group’) is given a intervention being tested (for example a drug, surgery, or exercise) is compared with a group which does not receive the intervention (the ‘control group’). (RCTs) comparing fluids warmed to body temperature, or just above, with unwarmed fluids and other means of warming the patient. They involved 1250 adults undergoing all types of surgery and excluding operations where the intention was that the patient would become cold. The review team planned to collect dataData is the information collected through research. on which patients became hypothermic (when their body temperature fell below 36 °C) but no trialsClinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. reported this, so they collected dataData is the information collected through research. on patients’ temperatures at time points throughout surgery. They also planned to collect dataData is the information collected through research. on cardiovascular complications.
Here’s what they found
- Patients given warmed fluids intravenously were about half a degree warmer and fewer of them shivered than those given fluids at room temperature
- Using warmed fluids for irrigation of body parts made no difference
- No evidence on other complications or length of stay in hospital
How good was the evidence?
The evidence was assessed as moderate quality. Unclear descriptions of trialClinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. design resulted in high or unclear riskA way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. of biasAny factor, recognised or not, that distorts the findings of a study. For example, reporting bias is a type of bias that occurs when researchers, or others (e.g. drug companies) choose not report or publish the results of a study, or do not provide full information about a study.. Apart from core temperature, the only other outcomeOutcomes are measures of health (for example quality of life, pain, blood sugar levels) that can be used to assess the effectiveness and safety of a treatment or other intervention (for example a drug, surgery, or exercise). In research, the outcomes considered most important are ‘primary outcomes’ and those considered less important are ‘secondary outcomes’. for which there was usable dataData is the information collected through research. in the trialsClinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. was shivering. It wasn’t possible for the reviewers to make any judgement on the severity of shivering as no two studies used the same scale to assess it. Only some studies reported bleeding complications and used different measures, preventing meaningful analysis.
Where does this leave us?
Whilst this evidence shows that using warmed IV fluids keeps adult patients warmer, we don’t know if the difference is clinically meaningful. We also remain uncertain if there are other benefits or harms associated with using warmed fluid, or whether there is any benefit in combining warming methods, as a ceiling effect is likely when multiple methods are used.
Can extra insulation prevent hypothermia and its complications for adults having an operation?
The reviewers found 22 RCTs with patients having routine or emergency surgery. They excluded studies where patients were having head surgery, skin grafts, a procedure under local anaesthetic or were deliberately kept cold.
Here’s what they found
- No clear evidence that using reflective blankets or clothing increases body temperature compared with usual care
- Some evidence that forced air warming increases body temperature by 0.5°C to 1°C compared with extra insulation (mostly reflective blankets in these studies)
- No evidence on major cardiovascular outcomesOutcomes are measures of health (for example quality of life, pain, blood sugar levels) that can be used to assess the effectiveness and safety of a treatment or other intervention (for example a drug, surgery, or exercise). In research, the outcomes considered most important are ‘primary outcomes’ and those considered less important are ‘secondary outcomes’. and no clear effects on bleeding, shivering or length of stay in post-anaesthetic care
How good was the evidence
It was low quality, with poor reporting of trialClinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. design, and we can’t be confident about the results. The reviewers were also concerned about the potential for skewed results from theatre staff changing their behaviour when they knew ways of keeping the patient warm had changed.
Where does this leave us?
There is no clear benefit of extra thermal insulation compared with standard care and while forced air warming seems to maintain core temperature better (but based on poor evidence) it is unclear whether the difference is clinically meaningful. The findings do not contradict the recommendation made in the NICE guideline that forced air warming be used rather than added insulation.
How effective are simple interventions to prevent surgical site infection?
I’ll be blogging about this soon, looking at the latest evidence on the effects of preoperative showering or bathing with skin antiseptics, the use of plastic drapes and surgical wound dressings.
There’ll be no blog next week as we’ll be running our annual two day symposium on 23rd and 24th but do join in on Twitter with the hashtag #CochraneAdvocate. You can see the programme here https://dublin2015.cochrane.org
Links:
National Collaborating Centre for Nursing and Supportive Care. National Institute for Health and Clinical Excellence (commissioner). The management of inadvertent perioperative hypothermia in adults. London: National Institute for Health and Clinical Excellence; 2008. (NICE CG65). [Issued April 2008; next review March 2015]. Available from: https://www.nice.org.uk/guidance/cg65/evidence/cg65-perioperative-hypothermia-inadvertent-full-guideline2
Campbell G, Alderson P, Smith AF, Warttig S. Warming of intravenous and irrigation fluids for preventing inadvertent perioperative hypothermia. Cochrane Database of Systematic ReviewsIn systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. 2015, Issue 4. Art. No.: CD009891. DOI: 10.1002/14651858.CD009891.pub2.
Alderson P, Campbell G, Smith AF, Warttig S, Nicholson A, Lewis SR. Thermal insulation for preventing inadvertent perioperative hypothermia. Cochrane Database of Systematic ReviewsIn systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. 2014, Issue 6. Art. No.: CD009908. DOI: 10.1002/14651858.CD009908.pub2.