If you ever nurse people with diabetes (that’s most of you, I think), then keep reading!
Yesterday was World Health Day, which this year focused on diabetes, and the World Health Organization published its first global report on diabetes. It’s well worth reading and there are useful resources accompanying it. Yesterday I blogged about preventing type 2 diabetes, but here I want to share some of the Cochrane Reviews are systematic reviews. In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. More on foot ulcers in people with diabetes.
About foot ulcers in people with diabetes
Foot ulcers in people with diabetes are commonly caused by peripheral neuropathy (nerve damage), foot deformity (associated with motor neuropathy), peripheral vascular disease, and peripheral oedema. External trauma is often the beginning of the process of ulceration. The loss of sensation associated with nerve damage (sensory neuropathy) experienced by many people with diabetes means that small injuries can go unnoticed; impaired blood supply may delay healing and infection increases the amount of damaged tissue at the site of the wound.
Being over 75 years of age increases the A way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. More of foot ulcers, as does the use of insulin, the length of time living with diabetes, poor psychosocial status, hyperkeratosis (thickening of the outermost layer of skin) and macrovascular and microvascular complications.
Infected, non-healing foot ulcers can result in limb amputation. 85% of all non-traumatic lower limb amputations in people with diabetes are preceded by a foot ulcer. Diabetes UK reports that there are more than 135 leg, foot or toe amputations in England alone each week and that up to 80% can be avoided with good diabetes management and foot care. Four years ago, Diabetes UK launched their Putting Feet First campaign, which includes a leaflet to help people with diabetes improve the quality of their foot checks and preventing foot ulcers in the first place is key.
Preventing foot ulcers
I went to this Cochrane review on complex interventions for preventing diabetes-related foot ulcers, published last year, full of hope, but sadly the evidence is really poor and the authors were left to conclude that “there is no high-quality research evidence evaluating complex interventions for preventing diabetic foot ulceration and insufficient evidence of benefit”.
How about patient education then? The Cochrane review on patient education for preventing diabetic foot ulceration found only short term gains in knowledge and self-care and we still don’t know if there is any benefit in terms of a reduction in ulcers and amputations.
So, what about your diabetic patients who present with foot ulcers?
Glycaemic control for treating foot ulcers
Control of hyperglycaemia may be important for ulcer healing. A new Cochrane review aimed to bring together RCTs comparing the effects of intensive glycaemic control compared with conventional control on the outcome of foot ulcers in people with type 1 or type 2 diabetes. There were no completed Clinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. More with results. The reviewers identified two ongoing trials and hope that these will have results for inclusion in a future update of the review. Meanwhile, the potential benefits and harms of intensive glycaemic control remain unclear.
Interestingly, recruitment to the trial of intensive glycaemic control was very difficult and the authors reported negative attitudes from participants, with the number of additional consultations needed and people’s ability to tolerate the potential side effects of intensive glycaemic control being contributory factors. The review includes a useful discussion of considerations for future research.
Relieving the pressure
A Cochrane review (14 studies, 709 people) found that non-removable pressure-relieving casts are more effective for healing diabetes-related plantar foot ulcers than removable casts or dressings alone. You can read more about this evidence in my earlier blog.
There is evidence that growth factors may be useful for increasing complete wound closure of diabetes-related foot ulcers, but the Cochrane review exploring this found only low quality studies (as assessed by GRADE), so better research is needed to strengthen or reject this finding. Let’s hope new studies address other important Outcomes are measures of health (for example quality of life, pain, blood sugar levels) that can be used to assess the effectiveness and safety of a treatment or other intervention (for example a drug, surgery, or exercise). In research, the outcomes considered most important are ‘primary outcomes’ and those considered less important are ‘secondary outcomes’. More too, such as quality of life, time to complete healing and lower limb amputation.
Debridement is the removal of dead, contaminated or foreign material from within or next to to a wound, until the surrounding healthy tissue is exposed. It’s often done to promote ulcer healing. A Cochrane review on debridement of diabetes-related foot ulcers found some evidence to suggest that hydrogel speeds healing compared with gauze dressings or standard care, but hydrogel works through increasing the moisture of the wound environment and whether the effect is brought about through debridement as such is unclear. There was very little evidence on surgical debridement or larval therapy. Once again, better quality trials are needed.
To help meet the need for reliable evidence to help purchasers, practitioners and patients make informed choices about which dressings to use, teams from Cochrane Wounds have carried out a number of In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. More on different dressings for treating foot ulcers in people with diabetes.
Hydrogel features again in the review on hydrogel dressings, which finds that hydrogel dressings are probably more effective than basic wound contact dressings in healing foot ulcers in people with diabetes, but that it is not known how they compare with other advanced wound dressings. There is a great variety of these and so last year a Cochrane team simplified things for us by pulling together, in an overview of reviews, 13 systematic reviews (six Cochrane and seven non-Cochrane) with 17 Randomization is the process of randomly dividing into groups the people taking part in a trial. One group (the intervention group) will be given the intervention being tested (for example a drug, surgery, or exercise) and compared with a group which does not receive the intervention (the control group). More A trial in which a group (the ‘intervention group’) is given a intervention being tested (for example a drug, surgery, or exercise) is compared with a group which does not receive the intervention (the ‘control group’). More (RCTs) on dressings for diabetes-related foot ulcers. Surely this is what you need to know to make sure your practice is evidence-informed? Well I’m afraid that, for now, we have to settle for knowing what we don’t know, as here’s the conclusion:
“There is currently no robust evidence for differences between wound dressings for any outcome in foot ulcers in people with diabetes (treated in any setting). Practitioners may want to consider the unit cost of dressings, their management properties and patient preference when choosing dressings.”
The WHO’s call to action includes addressing gaps in the diabetes knowledge base and these reviews, and the overview, have certainly revealed some important holes in the evidence base.
What do you do?
How do you care for people with diabetes-related foot ulcers in your clinical areas? Students, what are you taught about this aspect of care? I’d be interested to hear! As well as leaving comments here, you can join the conversation on Twitter, where I tweet for @ukcochranecentr and as @SarahChapman30. You can also find @CochraneWounds there. Don’t forget the #EENursing hashtag!
Foot ulcers in people with diabetes: evidence round-up by Sarah Chapman is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Based on a work at http://www.cochranelibrary.com. Images have been purchased for Evidently Cochrane from stock.com and may not be reproduced.
World Health Organization. “World Health Day 2016: WHO calls for global action to halt rise in and improve care for people with diabetes”. [Press release]. World Health Organization, Media Centre, 6 April 2016. Web. 7 April 2016.http://www.who.int/mediacentre/news/releases/2016/world-health-day/en/
World Health Organization. Global Report on Diabetes. Geneva: World Health Organization; 2016. Available from:http://www.who.int/diabetes/global-report/en/
National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. London: National Institute for Health and Care Excellence; 2015. (NICE NG19). [Issued August 2015]. Available from:http://www.nice.org.uk/guidance/NG19/evidence
Complex interventions for preventing diabetic foot ulceration. Cochrane Database of Systematic Reviews 2015, Issue 8. Art. No.: CD007610. DOI: 10.1002/14651858.CD007610.pub3., , , .
Patient education for preventing diabetic foot ulceration. Cochrane Database of Systematic Reviews 2014, Issue 12. Art. No.: CD001488. DOI: 10.1002/14651858.CD001488.pub5., , , .
Fernando ME, Seneviratne RM, Tan YM, Lazzarini PA, Sangla KS, Cunningham M, Buttner PG, Golledge J. Intensive versus conventional glycaemic control for treating diabetic foot ulcers. Cochrane Database of Systematic Reviews 2016, Issue 1. Art. No.: CD010764. DOI: 10.1002/14651858.CD010764.pub2.
Pressure-relieving interventions for treating diabetic foot ulcers. Cochrane Database of Systematic Reviews 2013, Issue 1. Art. No.: CD002302. DOI: 10.1002/14651858.CD002302.pub2., .
S. Chapman. “Non-removable casts are better than non-removable casts or dressings for helping diabetes-related foot ulcers heal.” Evidently Cochrane. 19 February 2013. Web 08 April 2016 https://www.evidentlycochrane.net/non-removable-casts-are-better-than-dressings-or-removable-casts-for-helping-diabetes-related-foot-ulcers-heal/
Debridement of diabetic foot ulcers. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD003556. DOI: 10.1002/14651858.CD003556.pub2., .
Hydrogel dressings for healing diabetic foot ulcers. Cochrane Database of Systematic Reviews 2013, Issue 7. Art. No.: CD009101. DOI: 10.1002/14651858.CD009101.pub3., , , .
Dressings for treating foot ulcers in people with diabetes: an overview of systematic reviews. Cochrane Database of Systematic Reviews 2015, Issue 7. Art. No.: CD010471. DOI: 10.1002/14651858.CD010471.pub2., , , , .