Clinical significance is the practical importance of an effect (e.g. a reduction in symptoms); whether it has a real genuine, palpable, noticeable effect on daily life. It is not the same as statistical significanceA statistically significant result is one which is unlikely to have happened by chance. This is not the same thing as clinical significance.. For instance, showing that a drug lowered the heart rateThe speed or frequency of occurrence of an event, usually expressed with respect to time. For instance, a mortality rate might be the number of deaths per year, per 100,000 people. by an average of 1 beat per minute would not be clinically significant, as it is unlikely to be a big enough effect to be important to patients and healthcare providers.
Clinically significant by Selena Ryan-Vig
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