As the cold, damp weather arrives at last, our GP surgeries will be filling up with people suffering from A health condition (or episodes of a health condition) that comes on quickly and is short-lived. respiratory infections (ARIs). Lots of them will come out with a prescription for antibiotics, despite the fact that the majority of these coughs and colds are caused by viruses and won’t be helped by antibiotics. I think we’re becoming much more aware that antibiotics may not be the appropriate Something done with the aim of improving health or relieving suffering. For example, medicines, surgery, psychological and physical therapies, diet and exercise changes. for these illnesses, but the primary care doctor has a difficult course to navigate, trying to avoid under-prescribing to those who have severe bacterial infections and over-prescribing to those who don’t. There’s no way of being sure, there and then, which patient’s illness is bacterial and which viral.
‘Inappropriate’ prescribing: bad for you, bad for health budgets
Antibiotic prescriptions are on the rise. Public Health England has found a 6% increase between 2010 and 2013 and say that up to half may be “inappropriate”. The growing problem of antibiotic resistance isn’t the only worrying consequence. Many of us will feel more unwell when taking antibiotics, as side effects are common. Furthermore, needless use of medicines wastes money.
A new report by the Academy of Medical Royal Colleges argues that doctors have an ethical duty to prevent waste in the NHS and the potential savings they point to include better use of medicines. Last month, Professor Laura Piddock, from the group Antibiotic Action, told the BBC “we have to make it easier for doctors to use antibiotics more wisely when the pressures in the NHS are great”.
3 minute test may help
Now, a new Cochrane review has promising evidence about a simple test that could guide GPs in prescribing antibiotics by helping them identify whether a patient with an ARI is likely to have a serious bacterial infection.
The reviewers gathered the best available evidence on the biomarker C-reactive protein, which gives information about how the body is responding to inflammation. It can be identified through a quick and simple test on a drop of blood from a finger prick, ready in three minutes. Low levels may rule out serious bacterial infection. Using the biomarker test was compared with standard care in six Clinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. with over 3000 people with ARIs, most of them adults.
Effective and safe?
They found that antibiotic use was 22% lower in the group that took the test and there was no difference in how long patients took to recover.
Overall, the test seems to be safe in its current form, but in one small trial those who took the test were more likely to be admitted to hospital at a later date. Lead reviewer Rune Aabenhus, from the Department of Public Health at the University of Copenhagen, commented: “This result may have been a chance finding, but it does remind us that general practitioners need to be careful about how they use these tests”.
How good is the evidence?
The evidence was classified as moderate according to GRADE; further research may change the results. The results varied a lot between studies, possibly due to differences in their design. This makes it more difficult to interpret the findings. The reviewers highlight the need for more evidence on how much the test could reduce antibiotic use. There are also things we still don’t know but would like to, such as how much money these tests could save and how their use compares to other antibiotic-saving methods.
Another approach to reducing antibiotic use in primary care is the use of a decision aid to help patients and doctors decide together whether to use antibiotics. You can see a great example in this video, showing a consultation between a doctor and a mother of a child with an ARI.
New in November 2015: A new Cochrane Reviews are systematic reviews. In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. has been published which shows that shared decision making between doctors and patients can reduce the use of antibiotics for acute upper respiratory tract infections. You can read the review here and a related Evidently Cochrane blog by GP Richard Lehman.
ESPAUR Writing Committee, Public Health England. English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR): report 2014. London: Public Health England; 2014. Available from: https://www.gov.uk/government/publications/english-surveillance-programme-antimicrobial-utilisation-and-resistance-espaur-report
Maughan D, Ansell J. Protecting resources, promoting value: a doctor’s guide to cutting waste in clinical care. London: Academy of Medical Royal Colleges; 2014. Available from: http://www.aomrc.org.uk/doc_download/9793-protecting-resources-promoting-value.html
Gallagher J. Antibiotic resistance rise continues. BBC News Health. BBC. 10 October 2014. Web. http://www.bbc.co.uk/news/health-29553435
Aabenhus R, Jensen JUS, Jørgensen KJ, Hróbjartsson A, Bjerrum L. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database of In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. 2014, Issue 11. Art. No.: CD010130. DOI: 10.1002/14651858.CD010130.pub2.
Cochrane summary http://summaries.cochrane.org/CD010130/ARI_use-of-rapid-point-of-care-testing-for-infection-to-guide-doctors-prescribing-antibiotics-for-acute-respiratory-infections-in-primary-care-settings
The Cochrane Library, Wiley Press Room [online]. 2014. Antibiotics: On-the-spot tests reduce unnecessary prescriptions [press release]. 06 November 2014. Available from: http://eu.wiley.com/WileyCDA/PressRelease/pressReleaseId-113702.html?dmmsmid=89174&dmmspid=22624367&dmmsuid=2343155
Page last updated 15 November 2015