There is evidence that free radicals may contribute to the processes of cognitive impairment and so there has been considerable interest in recent years in whether vitamin E with its potential to protect against the damaging effects of free radicals might be useful in the Something done with the aim of improving health or relieving suffering. For example, medicines, surgery, psychological and physical therapies, diet and exercise changes. More of mild cognitive impairment (MCI) and Alzheimer’s dementia (AD). The Cochrane Dementia and Cognitive Improvement Group has updated its review exploring this approach, which now includes two Randomization is the process of randomly dividing into groups the people taking part in a trial. One group (the intervention group) will be given the intervention being tested (for example a drug, surgery, or exercise) and compared with a group which does not receive the intervention (the control group). More Clinical trials are research studies involving people who use healthcare services. They often compare a new or different treatment with the best treatment currently available. This is to test whether the new or different treatment is safe, effective and any better than what is currently used. No matter how promising a new treatment may appear during tests in a laboratory, it must go through clinical trials before its benefits and risks can really be known. More involving people with AD and one with people with MCI, comparing vitamin E with An intervention that appears to be the same as that which is being assessed but does not have the active component. For example, a placebo could be a tablet made of sugar, compared with a tablet containing a medicine. More.
What did they find?
No or little benefit from using vitamin E to treat AD or MCI
How good is the evidence?
Data is the information collected through research. More from the studies could not be combined as the two AD studies had different Outcomes are measures of health (for example quality of life, pain, blood sugar levels) that can be used to assess the effectiveness and safety of a treatment or other intervention (for example a drug, surgery, or exercise). In research, the outcomes considered most important are ‘primary outcomes’ and those considered less important are ‘secondary outcomes’. More measures: performance-based tasks in one and reaching certain end points (such as institutionalisation or loss of activities of daily living) in the other. The MCI An investigation of a healthcare problem. There are different types of studies used to answer research questions, for example randomised controlled trials or observational studies. More needed to be evaluated separately as it involved people with one particular type of MCI
The methods used were not always fully reported
One study had high drop-out rates and did not give reasons for this
The reviewers make some important points. They highlight that other research has shown that vitamin E, especially in the large doses used in treatment studies, may be associated with potentially serious side effects. Taken alongside the lack of evidence for its The ability of an intervention (for example a drug, surgery, or exercise) to produce a desired effect, such as reduce symptoms. More, they recommend that vitamin E should not be used for the treatment of Alzheimer’s dementia and mild cognitive impairment. They also recommend that future trials should not be restricted to the alpha-tocopherol form of vitamin E and should consider assessing oxidant-antioxidant balance to determine whether the vitamin E treatment is having the desired effects.
Farina N, Isaac MGEKN, Clark AR, Rusted J, Tabet N. Vitamin E for Alzheimer’s dementia and mild cognitive impairment. Cochrane Database of In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. More 2012, Issue 11. Art. No.: CD002854. DOI: 10.1002/14651858.CD002854.pub3. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002854.pub3/abstract;