In this blog for people with intermittent claudication, Dr Rebecca Gould, Sport and Exercise Medicine Registrar and Cochrane UK Fellow, looks at the latest Cochrane Reviews are systematic reviews. In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. More on exercise for intermittent claudication and explores if the type of exercise undertaken makes a difference.
Intermittent claudication is the medical term used to describe lower leg pain that comes on during exercise (for example, walking). The pain usually goes away after a few minutes of rest and is a symptom of peripheral arterial disease (a condition where a build-up of fatty deposits in the arteries reduce blood supply to the leg muscles). Intermittent claudication can greatly affect a person’s day to day life by causing pain and discomfort. It can also limit how far they can walk, and stop them taking part in activities and hobbies.
Something done with the aim of improving health or relieving suffering. For example, medicines, surgery, psychological and physical therapies, diet and exercise changes. More of intermittent claudication has two aims: 1) to improve symptoms and 2) to reduce the A way of expressing the chance of an event taking place, expressed as the number of events divided by the total number of observations or people. It can be stated as ‘the chance of falling were one in four’ (1/4 = 25%). This measure is good no matter the incidence of events i.e. common or infrequent. More of developing other cardiovascular diseases (such as heart attacks or strokes). National guidelines (NICE 2018) recommend exercise for both treatment aims, but in this blog I will focus on exercise and its effect on the symptoms of intermittent claudication.
What we know already about exercise for intermittent claudication
For people with intermittent claudication, national guidelines recommend they take part in a supervised exercise programme, ideally for two hours a week for three months (NICE 2018). Supervised exercise programmes often take place at a hospital and are typically supervised by a specialist nurse or physiotherapist. The main exercise performed is often walking, but other forms of exercise can be done like cycling on an exercise bike, or strength training. For people with intermittent claudication, it is recommended that they exercise to the point where they get leg pain and are unable to continue because of this (this is called maximal leg pain). Once maximal leg pain is reached, there is a brief period of rest (which allows the leg pain to go away), and the cycle of exercise, followed by a period of rest, is then repeated for the duration of the session.
It may seem contradictory for people with intermittent to do exercise, when this is the thing that brings on symptoms. However, exercise is thought to improve the blood supply to the legs by stimulating the body to make existing blood vessels more effective and build new ones (Haas et al. 2012) .
Exercise increases how far people with intermittent claudication can walk
There is reliable (high-certainty) evidence from a Cochrane Reviews are systematic reviews. In systematic reviews we search for and summarize studies that answer a specific research question (e.g. is paracetamol effective and safe for treating back pain?). The studies are identified, assessed, and summarized by using a systematic and predefined approach. They inform recommendations for healthcare and research. More ‘Exercise for intermittent claudication‘ (published December 2017) that exercise increased how far people with stable intermittent claudication could walk on a treadmill, both without pain (on average 82m further) and in total (on average 120m further). The review authors also found exercise may improve quality of life but were uncertain if exercise made any difference to the numbers of people who ended up needing an amputation or dying during the period they were followed up by the researchers.
Exercise in the included studies was generally supervised and performed twice a week, for at least 3 months. The type of exercise differed and included walking, strength training, and upper and lower body exercises.
Does the type of exercise make a difference in intermittent claudication?
So, we have seen that exercise can improve how far someone with intermittent claudication is able to walk but does the type of exercise performed make a difference? It seems that it does.
Supervised versus home-based walking exercise programmes versus walking advice
A Cochrane Review from April 2018, looked at supervised exercise programmes compared with home-based exercise programmes or walking advice alone. In both, walking was the most common exercise. For the supervised exercise group, walking was typically performed on a treadmill for 3 sessions a week with each session being between 30 and 70 minutes. Those in the home-based exercise groups received an exercise ‘prescription’ recommending how much exercise to do (typically walking, three sessions per week between 30 and 50 minutes, for at least 3 months) and had follow-up with a healthcare professional, either face-to-face or by telephone, to review their progress. In some studies, the home exercise group were also provided with ways of recording their activity such as a logbook or pedometer. The walking advice groups were encouraged to walk more but did not have receive any further support.
The authors found that supervised exercise increased the total distance people could walk on a treadmill by approximately 210m compared with walking advice (high-certainty evidence) and probably increased it by around 120m compared to home-based exercise (The certainty (or quality) of evidence is the extent to which we can be confident that what the research tells us about a particular treatment effect is likely to be accurate. Concerns about factors such as bias can reduce the certainty of the evidence. Evidence may be of high certainty; moderate certainty; low certainty or very-low certainty. Cochrane has adopted the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) for assessing certainty (or quality) of evidence. Find out more here: https://training.cochrane.org/grade-approach More evidence). Supervised exercise programmes also increased how far people could walk pain free on a treadmill.
The authors also found that when compared to home-based exercises, supervised exercise programmes did not effect quality of life or self-reported functional impairment but when compared to walking advice, supervised exercise programmes may improve self-reported functional impairment and some measures of quality of life (such as physical functioning and pain). The authors found no difference in functional impairment or quality of life between home-based and walking advice groups. There was no evidence of a difference in death rates between groups.
Alternative modes of supervised exercise versus supervised walking exercise
Supervised exercise, then, offers some benefits over home-based exercise or advice on walking. A Cochrane Review ‘Modes of exercise training for intermittent claudication‘, published in August 2020, has explored this further, bringing together evidence comparing a variety of different supervised exercises (including lower and/or upper body strength training, Nordic walking, cycling or a combination of exercises) with supervised walking exercises (at least twice a week for 6 weeks).
The review authors concluded that supervised walking and other types of supervised exercise programmes may have similar effects on how far people with intermittent claudication can walk in total, and for how far they can walk without pain (low-certainty evidence). This means that alternative types of supervised exercise may be useful when supervised walking exercise programmes are not an option.
What about other treatments?
Other treatments such as angioplasty or stenting (procedures to widen blocked or narrowed arteries) are generally reserved for people who have not had a satisfactory improvement in symptoms in an exercise programme. A Cochrane Review from March 2018 compared angioplasty and stenting to supervised exercise in people with stable intermittent claudication, and found in the long-term no evidence of a difference in how far people could walk (without pain and total distance), or in quality of life.
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Rebecca Gould has nothing to disclose.