Treatments to prevent travel sickness: a quick look

In this short blog, Dr Robert Walton looks at the evidence on treatments to prevent travel sickness (motion sickness).

Take-home points

Take-home points: Effective preventative treatments are available for travel sickness The choice is between hyoscine and older ‘first generation’ antihistamines New Cochrane evidence shows that some antihistamines are likely to reduce the risk of travel sickness in adults. They may cause drowsiness

The new evidence on antihistamines comes from the Cochrane Review Antihistamines for motion sickness (published in October 2022) and is relevant to adults.

Travel sickness (motion sickness) is a common problem, and many people experience nausea for example on boats, planes or in the car. Lots of treatments which aim to prevent travel sickness are available to buy in UK pharmacies, including medicines. Here is the evidence on these medicines and some things you may want to think about when making your choices.

Making a choice? Think BRAIN!

It can be helpful to think BRAIN: What are the Benefits, Risks, Alternatives, what do I want and what if I do Nothing? These can be good questions to talk about with a health professional when making a health decision.

Medicines to prevent travel sickness

The choice is between hyoscine (or scopolamine as it is sometimes called) and antihistamines such as cinnarizine.

Most of the Cochrane evidence is focused on hyoscine which is probably better than placebo (dummy treatment) at preventing travel sickness.  It comes from the Cochrane Review Scopolamine (hyoscine) for preventing and treating motion sickness (published June 2011).

The new Cochrane evidence about antihistamines, from the Cochrane Review Antihistamines for motion sickness (published October 2022) finds that they are likely to reduce the risk of travel sickness in adults who tend to get it, compared with taking a placebo.

It’s worth bearing in mind that there is evidence to support using older or ‘first generation’ antihistamines but none for the newer medicines such as loratadine and cetirizine which are more commonly used now for hay fever now.  These newer antihistamines are not used to prevent or treat motion sickness and are unlikely to be effective.

There are few studies comparing the two types of medicines.  There is little information about whether either are useful for treating motion sickness after it has started so prevention may be better than cure.

What are the risks?

Hyoscine and antihistamines both work in the same way for preventing travel sickness and they also share the same side effects which include drowsiness in some people.

What are the other options?

Many other options are available but there is no Cochrane evidence about their potential benefits and harms.

What do I want?

What matters (most) to you, and past experiences of a problem – and of treatments, is important when making treatment choices. If you usually get travel sickness and want to prevent it then there are medicines that can help and are backed up by Cochrane evidence. But it may be important to you to avoid the risk of side effects (such as drowsiness, if you have to drive for example). You could discuss your options and experience of treatments with a pharmacist.

What if I do nothing?

Travel sickness is usually not usually a big problem although some people can be quite severely affected.  If you have had it once in a particular situation then you are likely to get it again.

Find out more

NHS pages on motion sickness

The Cochrane Reviews:

Karrim N, Byrne R, Magula N, Saman Y. Antihistamines for motion sickness. Cochrane Database of Systematic Reviews 2022, Issue 10. Art. No.: CD012715. DOI: 10.1002/14651858.CD012715.pub2.

Spinks A, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews 2011, Issue 6. Art. No.: CD002851. DOI: 10.1002/14651858.CD002851.pub4.

Why you can trust this information

Join in the conversation on Twitter with @CochraneUK @rtwalton123 or leave a comment on the blog. 

Please note, we cannot give specific medical advice and do not publish comments that link to individual pages requesting donations or to commercial sites, or appear to endorse commercial products. We welcome diverse views and encourage discussion but we ask that comments are respectful and reserve the right to not publish any we consider offensive. Cochrane UK does not fact-check – or endorse – readers’ comments, including any treatments mentioned.

Robert Walton has nothing to disclose.



Treatments to prevent travel sickness: a quick look by Robert Walton

is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International

1 Comments on this post

  1. Dr. Walton, thank you for sharing your review. For children and those children with epilepsy, I have looked at their sensory processing to help prevent some of their motion sickness. There is a book “Understanding your Child’s Sensory Signals” by Angie Voss, OTR that helps families. I can also share with you my poster from the British Paediatric Neurology Association event in 2020 titled ” What are the perspectives and understanding of healthcare professionals including occupational therapists on treatment and care of babies with infantile spasms and early onset epilepsy- A qualitative design” if I have your email address.

    Deanna Middleton / Reply

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