Antibiotic Awareness: A round up of Cochrane evidence

In 2017, Professor Dame Sally Davies, England’s Chief Medical Officer, warned that the world could face a “post-antibiotic apocalypse.” She urged that, unless action is taken to halt the practices that have allowed antibiotic resistance to spread and ways are found to develop new types of antibiotics, we could return to the days when simple wounds, infections or routine operations, are life-threatening.

To mark World Antibiotic Awareness Week, 12th-18th November 2018, we are highlighting Cochrane evidence which supports decision-making in the appropriate use of antibiotics. Below is a round up of blogs and infographics (blogshots and vlogshots).

Blog post: Antibiotic resistance – bacteria fighting back by Samantha Gale, Cochrane UK’s Public Health Fellow.

Blog post: Apocalypse now – antimicrobial resistance by Lynda Ware, Cochrane UK’s Senior Fellow in General Practice.

Blog post: Why should I care about antibiotic resistance? by the Cochrane Trainees.

Shared decision making and antibiotic use for acute respiratory infections in primary care (Press release; also available in Spanish).

shared decision making antibiotics

Improving antibiotic prescribing in hospital


Improving antibiotic prescribing

Antibiotics for preventing recurrent sore throat

Antibiotics for sore throat

antibiotics sore throat

Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections

Procalcitonin antibiotics

Biomarkers as point-of-care tests to guide antibiotic use for acute respiratory infections

Biomarkers antibiotics

Antibiotics for acute otitis media in children

Antibiotics for acute otitis media in children

Antibiotics for glue ear

Antibiotics for glue ear

Rapid antigen detection tests (RADTs) for group A streptococcus (GAS) in children with pharyngitis

rapid antigen detection tests

Antibiotics for operative vaginal delivery?

Compared with placebo or no treatment, prophylactic antibiotics reduce serious infectious complications and deep and superficial perineal wound infection (high‐certainty evidence), and probably reduce wound breakdown (moderate‐certainty evidence). Effects on organ or space perineal wound infection, maternal length of stay or endometritis are uncertain (low-certainty evidence). The studies did not report on maternal fever or urinary tract infection. It is uncertain whether prophylactic antibiotics have any impact on maternal adverse reactions (low-certainty evidence). The studies did not report on neonatal adverse reactions. Cochrane Review (published March 2020); two studies with 3813 women undergoing either vacuum or forceps deliveries. One study (3420 women) compared intravenous amoxicillin and clavulanic acid with placebo. The other study (393 women) compared intravenous cefotetan after cord clamping with no treatment.

Routine antibiotic prophylaxis after normal vaginal birth for reducing maternal infectious morbidity

Antibiotics for episiotomy repair?

Antibiotics for episiotomy repair?

Antibiotic prophylaxis for women having cesarean section

antibiotics for CSection

Timing of IV prophylactic antibiotics for women having caesarean delivery

Timing antibiotics CSection

Preventing post-cesarean infections: which route for antibiotics?

Caesarean antibiotics

Oral vs inhaled antibiotics for bronchiectasis

Continuous versus intermittent antibiotics for bronchiectasis

Antibiotics for exacerbations of COPD

antibiotics for COPD

Antibiotics for asymptomatic bacteriuria in kidney transplant recipients

Antibiotics for irreversible pulpitis

Feature on Cochrane Oral Health

antibiotics for pulpitis

Antibiotics for chronic rhinosinusitis

Chronic rhinosinusitis antibiotics

Pre-admission antibiotics for suspected meningococcal disease

 Pre-admission antibiotics meningococcal

Short- vs. long-course intravenous antibiotics for severe pneumonia in children aged 2-59 months

antibiotics for severe pneumonia

Prophylactic antibiotics after cervical excision

Prophylactic antibiotics after cervical excision

Antibiotics for cough or wheeze after acute bronchiolitis in children

Editor’s note: page last updated 15th October 2018.

Selena Ryan-Vig

About Selena Ryan-Vig

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Selena Ryan-Vig is the Communications and Engagement Officer at Cochrane UK. Her role primarily entails disseminating Cochrane evidence in accessible ways, managing Cochrane UK's website and social media accounts, and producing newsletters and infographics. With a colleague, Selena delivers interactive sessions to students from Years 10 to 13 to teach about evidence-based practice and to encourage critical thinking, particularly around healthcare claims made in the media. She also co-delivers talks for students to raise awareness of Cochrane and reliable, evidence-based resources. She has a psychology degree from the University of Bath. During her degree, she spent a placement year working in a national charity which provides support for young women affected by self-injury and training for professionals working with individuals who self-injure.

1 Comments on this post

  1. Avatar

    It’s quite frightening in a way how little we actually do know about such a ubiquitous treatment.

    Roger Harrison / Reply

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